In the rural site, 114 (44%) were infected and 24 (9%) had multiple infections. In the urban site, 161 (64%) children were infected and 65 (26%) had ≥2 infections. Results Cryptosporidium infections were common at both sites and mostly subclinical. Stool samples were collected monthly and during diarrheal episodes with Cryptosporidium infection and causative species determined by quantitative polymerase chain reaction assays. For 2 years, the children were actively monitored for diarrhea and anthropometric measurements were obtained every 3 months. Their offspring were enrolled at birth into the study (urban, n = 250 rural, n = 258). Methods Pregnant women in the second trimester were identified at 2 sites in Bangladesh, 1 urban and 1 rural. This study investigated the burden of cryptosporidiosis and its impact on child growth in both a rural and an urban site in Bangladesh.
Cid episode 1347 registration#
Clinical Trials Registration NCT02764918.Ībstract = "Background Cryptosporidiosis is a major cause of childhood diarrhea in low- and middle-income countries and has been linked to impairment of child growth. Predominant Cryptosporidium species differed between the 2 sites, suggesting different exposures or modes of transmission but similar consequences for child growth. Conclusions Cryptosporidiosis is common in early childhood and associated with early growth faltering in Bangladeshi children. The most common species in Mirpur was Cryptosporidium hominis, whereas Cryptosporidium meleagridis predominated in Mirzapur. Adjusted for potential confounders, cryptosporidiosis was associated with a significantly greater drop in the length-for-age z score (LAZ) at 24 months from LAZ at enrollment ("-LAZ), an effect greatest in the children with multiple episodes of cryptosporidiosis.
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Background Cryptosporidiosis is a major cause of childhood diarrhea in low- and middle-income countries and has been linked to impairment of child growth.